Nystatin

Nystatin

·        It is a polyene macrolide, similar in structure & mechanism to amphotericin B.

·        Too toxic for systemic use.

·        Used only topically.

·        It is available as creams, ointment, suppositories & other preparations.

·        Not significantly absorbed from skin, mucous membrane, GIT.

Clinical uses

·        Prevent or treat superficial candidiasis of mouth, esophagus, and intestinal tract.

·        Vaginal candidiasis

·        Can be used in combination with antibacterial agents & corticosteroids.