Other Beta-Lactam Antibiotics

:

1- Carbapenems:

Structurally related to beta-Lactum antibiotics. 

     A- Imipenem.

     B- Meropenem.

Imipenem has wide spectrum of activity.

    - Gram positive

    - Gram negative, and Anaerobes.

Meropenem has slightly less activity against gram positive bacteria.

Dose of Imipenem is 500 mg 6-8 hourly.

Half-life = 1 hour

Meropenem dose is 1 gm 8 hourly

They are used with or without aminoglycoside in febrile Neutropenic patients.

Patients allergic to penicillins can be allergic to Imipenem and Meropenem

2- Monobactums: (Aztreonam)

Active against gram negative rods (pseudomonas and serratia)

No activity against gram positive

Aztreonam given IV in dose 1-2 gm IV 8 hourly.