Hepatitis E Virus

·       Single stranded RNA, incubation period 6 weeks. 

·       Water-borne infection affecting young to middle-aged adults (oral route).

·       Causes acute self-limiting hepatitis.

·       Among pregnant women has a high mortality rate (20%).

HIV and Chronic Viral Hepatitis

·       Because of similar transmission mode & similar high-risk patient population, co-infection of HIV & HVs is now a common   clinical problem 

·       HIV infection exacerbates the severity of  liver disease caused by HBV or HCV

·       Less clear is the impact of HBV or HCV on the course of HIV infection

·       In addition, anti-HIV agents may cause hepatotoxicity in some patients with HBV or HCV co-infection